This Week in Startups

Jason Calacanis
This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

  1. 70mph Drone Deliveries, 125% Tariffs & What $10M Exits Really Mean | E2109

    22H AGO

    70mph Drone Deliveries, 125% Tariffs & What $10M Exits Really Mean | E2109

    Today’s show: Jason, Alex, and Lon talk about stories reshaping the startup world: 70mph drone deliveries are officially live in Dallas, with Zipline and Walmart promising groceries “as the crow flies” in under 5 minutes. Meanwhile, Trump slaps a 125% tariff on China and hints at a global economic shakeup — Jason warns founders to brace for layoffs and bankruptcies unless they’ve got a Plan B and C. Finally, a UK startup sells for $450M and VCs barely break even… but the founders walk with $20M. Jason explains how small exits create the most dangerous kind of founder: the one who never needs another check. Plus Office Hours with Orchestra CEO Sergie Poe. Timestamps: (0:00) Jason kicks off the show!(1:37) Tariffs, market volatility, and startup implications(5:33) Startup resilience: Layoffs and bankruptcies(10:35) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions(12:10) Globalization and startup ecosystems(13:52) Recent startup deals and Zipline's expansion(19:56) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist(21:16) Zipline drones and Marquese Brownlee’s review(24:31) 70MPH Drones and the future of ddeliveries(30:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(31:51) Founder FridaysPitch Madness matchups(33:35) LifeStack and Burble pitches and discussion(43:26) Arcana and Tactun pitches and discussion(50:12) Summer West Whiskey and MomSub pitches and evaluation(56:36) Orchestra's office hours: Challenges and strategies Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Links from the show: Orchestra: https://orch.so/ Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (10:35) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions (19:56) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist (30:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 7m
  2. 2D AGO

    Economic Chaos, More Pitch Madness & the Shopify AI Manifesto | E2108

    Today’s show: Jason and Alex unpack a wild week in tech and the markets — including a fake tweet that moved $4 trillion and Trump’s latest tariff talk. Lon jumps in for another round of Founder Fridays Pitch Madness, where four early-stage startups compete for a spot in the Elite Eight. Plus, Alex chats with Sunny Khamkar, CEO of MenuData, about how AI is revolutionizing the food industry. They also dive into how founders should rethink their runway, what Shopify’s bold AI memo means for the future, and whether VCs are placing earlier bets to chase that $1M ARR milestone. Don’t miss the founder pitches and a fresh take on AI-powered food trend tracking! * Timestamps: (0:00) Jason kicks off the show! (2:11) Market chaos, tariffs, and their effects (5:59) Economic uncertainty: Advice for founders (8:00) Tariffs' potential impact on tech sectors (9:58) Fidelity Private Shares℠ - Visit ⁠https://www.fidelityprivateshares.com ⁠! Mention our podcast and receive 20% off your first-year paid subscription. (13:27) SignalFire's billion-dollar fund (17:32) Achieving significant startup revenue and its importance (20:20) Coda - Empower your startup with Coda’s Team Plan for free—get 6 months at https://www.Coda.io/twist (21:54) Krea's $87 million raise and subscription model analysis (27:33) Big tech's influence on niche subscription services (30:02) Gusto - Get three months free when you run your first payroll at http://gusto.com/twist (31:09) AI advancements: Midjourney v7 and voice activation (36:43) Shopify's AI Manifesto (41:00) Founder Friday bracket updates (57:16) Founder Q&A: Lessons for first-time founders (1:05:00) MenuData's CEO Sunny Khamkar interview (1:16:10) MenuData's pricing, customer base, and growth plans (1:23:38) AI's vertical impact and Menu Data's strategy * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Links from the show: Check out MenuData: https://www.menudata.ai/ Check out Krea: https://www.krea.ai/ Check out Tobi Lutke’s ”AI Manifesto” https://x.com/tobi/status/1909251946235437514 Check out Pitchfire: https://www.pitchfire.com/ Check out CREATANT: https://www.creatant.com/ Check out Vidala Labs: https://vidalalabs.com/ Check out Kippy: https://kippy.ai/ Follow Sunny Khamkar: LinkedIn: https://www.linkedin.com/in/sunny-khamkar-84b905a * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Lon: X: https://x.com/Lons LinkedIn: https://www.linkedin.com/in/lonharris * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (9:58) Fidelity Private Shares℠ - Visit ⁠https://www.fidelityprivateshares.com ⁠! Mention our podcast and receive 20% off your first-year paid subscription. (20:20) Coda - Empower your startup with Coda’s Team Plan for free—get 6 months at https://www.Coda.io/twist (30:02) Gusto - Get three months free when you run your first payroll at http://gusto.com/twist * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 27m
  3. 5D AGO

    Rippling Targets $16B, Market Chaos, TikTok Timeout, and Office Hours | E2107

    Today’s show: Jason and Alex dive into the startup world’s latest chaos — from Nasdaq’s slide and Trump’s tariffs to Klarna’s IPO pause and Rippling’s $16B target. They break down what founders really need to know: tightening CIO budgets, longer sales cycles, but easier hiring. Plus, TikTok’s ban gets another delay (with Bezos possibly lurking?). In Office Hours, they chat with two sharp founders: Luke Belbina from PodEngine, who's building AI for podcasters and doubling revenue, and David Moscatelli from Abacus, who’s bringing secure, on-prem AI to banks and just hit $1M ARR. Don’t miss it! 👇 * Timestamps: (0:00) Jason kicks off the show! [3:37] Cloud stocks dip: What it means for startups [5:31] Trump's tariffs: A new startup recession? [7:01] Retail’s reaction to tariff pressure [10:16] LinkedIn Ads - Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups [12:35] Supply chains & startup struggles [14:53] What’s still getting funded in VC [17:21] Layoffs looming? What founders should prep for [19:10] AI, macro takes & market signals [21:32] Northwest Registered Agent - Get a 60% discount on your next LLC at https://www.northwestregisteredagent.com/twist [23:21] European tech cooling off? [24:36] Hiring freezes vs. easier recruiting [27:39] Startup strategies in tough markets [29:34] Vapi - Go to https://vapi.ai/twist and get 1000 minutes free per month - for life. [31:38] How to communicate tough changes [33:33] TikTok ban delayed… again [39:38] Trump’s China playbook: Startup impact [42:12] Office Hours: Luke from PodEngine [47:31] Automating with AI & driving sales [55:53] Pricing, lead gen & scaling tips [1:06:30] Office Hours: David from Abacus [1:08:32] On-prem AI for banks + hitting $1M ARR [1:14:42] Team building & founder strategy * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Links from the show: Check out PodEngine: https://www.podengine.ai/ Check out Abacus: https://www.goabacus.co/ * Follow Luke: X: https://x.com/lukebelbina LinkedIn: https://www.linkedin.com/in/lukebelbina/ * Follow David: X: https://x.com/DaveMoscatelli * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: [10:16] LinkedIn Ads - Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups [21:32] Northwest Registered Agent - Get a 60% discount on your next LLC at https://www.northwestregisteredagent.com/twist [29:34] Vapi - Go to https://vapi.ai/twist and get 1000 minutes free per month - for life. Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 32m
  4. APR 3

    Spycraft in SaaS, Rabbit’s Comeback, and Startup Pitch Madness | E2106

    This Week in Startups is brought to you by… Kyte - TWIST Listeners: Go to https://kyte.com/ and download the Kyte app today. Use code JASON to save 10% on your first rental. Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months. Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Today’s show: Jason and Alex go deep into the shocking new details about the Rippling vs. Deel corporate espionage scandal—where a self-admitted spy fed confidential product roadmaps and sales data to a rival CEO for €5K/month. Plus, they interview Rabbit CEO Jesse Lyu about their bold comeback with their new “Intern” AI agent that builds entire apps from a single prompt - Jason calls it a breakthrough. And we kick off Pitch Madness with fierce Founder Friday pitch battles featuring AI podcast tools and women’s sports communities. Spy drama, next-gen tech, and raw founder energy—don’t miss it. Timestamps: (0:00) Teaser: Rippling vs. Deel Espionage Case(1:46) Podcast updates and listener engagement(2:31) Job openings at Launch and This Week in Startups(4:19) Rippling and Deel lawsuit details and espionage activities(9:58) Kyte - TWIST Listeners: Go to https://kyte.com/ and download the Kyte app today. Use code JASON to save 10% on your first rental.(11:31) Stolen information and the aftermath of the espionage case(16:21) Corporate espionage vs. corporate intelligence debate(19:38) Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months.(23:07) Board independence, whistleblower protections, and CEO behavior(25:10) Y Combinator's culture of rule bending(28:41) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(30:02) Jesse Lu's YC experience and launch of Rabbit(34:48) Navigating the hype cycle as a founder and RabbitOS demo(45:02) Estate management and technology with Rabbit(48:39) Conclusion of interview with Jesse Lu(48:51) Launching Founder Friday pitch offs(50:43) Pitch: Snipd - AI-powered podcast app(53:29) Pitch: MedSimple - Medical education platform(57:10) Pitch: Trova - Workplace connection platform(58:45) Pitch: Osprey - Community for women in sports and entertainment(1:05:30) Analysis and decision: MedSimple vs Snipped and Osprey vs Trova(1:09:23) Discussion on Osprey's business model(1:10:33) Tips for improving pitch presentations(1:11:02) Announcement of Twist 500 competition(1:11:46) Closing remarks and social media call to action Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Links from the show: Rabbit website: https://www.rabbit.tech/?srsltid=AfmBOorumixyS_kXbNPL2tDqLBsI08B4Hs3xUSZkOLS2nlKsatop5VG2 Follow Jesse:X: https://x.com/jessechenglyu LinkedIn: https://www.linkedin.com/in/jesselyu/ Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (9:58) Kyte - TWIST Listeners: Go to https://kyte.com/ and download the Kyte app today. Use code JASON to save 10% on your first rental. (19:38) Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months. (28:41) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 13m
  5. APR 1

    M&A Mania, Palantir Meme Crash + Office Hours with Hookhub | E2105

    Today’s show: Circle gears up for its IPO and the stablecoin wars heat up, Palantir’s meme stock status gets a reality check, and they riff on a possible Uber + DoorDash merger and whether AI should train on Substack content. They react to Sequoia partner Andrew Reed’s inside take on fund dynamics, laugh at a brutal VC meme, and wrap with “Office Hours” featuring Caylee Harrington, founder of Hookhub — the Airbnb for RV parking — to talk vanlife, growth, and building in an unsexy market. * Timestamps: (0:00) Alex and Jason kicks off the show! (1:29) Palantir's stock and market dynamics (5:43) Meme stocks and reversion to the mean (6:57) X and XAI merger (10:01) Squarespace - TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (12:05) M&A trends in tech and AI content acquisitions (17:22) Valuation strategies for acquisitions (22:05) Oracle - TWiST listeners can try OCI and save up to 50% on your cloud bill at ⁠⁠⁠https://www.oracle.com/twist⁠ (23:31) Circle's IPO and stablecoin regulations (30:46) Fidelity Private Shares - Visit ⁠https://www.fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription. (32:26) Crypto community and anti-money laundering in stablecoins (37:43) IPO and SPAC updates in tech (41:20) Deep tech investment risks and lessons from SPACs (44:03) Hookhub's journey and RV market insights (49:27) Growth and challenges in RV market (52:01) Hookhub's social media and content strategy (58:48) Hookhub's investor pitch and growth strategy (1:04:11) Van life business model potential (1:06:16) Sequoia's internal culture and investment strategy (1:13:03) Sequoia vs. Andreessen Horowitz and VC indexing (1:15:32) Venture capital humor and closing remarks * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Links from the show: Hookhub: https://www.hookhub.co/ * Follow Caylee: X: https://x.com/Mariano_APO LinkedIn: https://www.linkedin.com/in/mariano-apodaca-45b07a16a/ v Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (10:01) Squarespace - TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (22:05) Oracle - TWiST listeners can try OCI and save up to 50% on your cloud bill at ⁠https://www.oracle.com/twist⁠ (30:46) Fidelity Private Shares - Visit ⁠⁠https://www.fidelityprivateshares.com⁠⁠! Mention our podcast and receive 20% off your first-year paid subscription. * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 17m
  6. MAR 29

    AI Revolution Gains, Non-Consensus Startups & Prosperous AI | E2104

    Today’s show: Jason, Alex, and Lon cover everything from wild political headlines to big moves in AI and venture. They kick things off with the surprising Trump pardon of Trevor Milton, the disgraced Nikola founder, and break down CoreWeave’s rocky IPO debut. Then, Jason and Alex sit down with Mariano Apodaca, founder of Prosperous AI, to talk about AI tools for negotiating construction and aerospace material costs. Later, in a brand new segment called "Office Hours with JCal," Jason reacts to real founder feedback clips, pulls key startup lessons, and explains why building for a market that doesn’t yet exist might actually be your biggest edge. Along the way, the team explores the power of taking just 10% of the value you create — a pricing philosophy that could unlock your next big win. * Timestamps: (0:00) Jason kicks off the show! (4:05) Breaking news on CoreWeave and Founder University insights (9:21) Hubspot for Startups - Visit https://www.hubspot.com/startups and join the founders who are turning growth challenges into opportunities. (10:57) Trevor Milton's pardon and AnySphere's Cursor success (19:21) Pricing strategies for startups (20:19) Vanta - TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist (21:38) AI sentiment and startup growth strategies (25:14) Guest interview: Mariano from Prosperous AI (30:21) Notion - TWiST listeners can try it for free at https://notion.com/twist (31:52) Prosperous AI's market data integration and growth (35:03) Founder University's impact on Prosperous AI (40:54) Product line expansions and fundraising growth strategies (44:20) Startup decision-making and investor feedback (47:02) Founder University and customer feedback importance (51:12) Canva CEO's insights and handling investor rejection (58:17) Products creating new markets and finding outlier founders (1:06:15) Venture success with Fred Wilson and Brad Burnham (1:09:18) Market selection, execution, and partner-product fit in startups * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Links from the show: Prosperous AI: https://prosperousprocess.ai/ * Follow Mariano: X: https://x.com/Mariano_APO LinkedIn: https://www.linkedin.com/in/mariano-apodaca-45b07a16a/ * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (9:21) Hubspot for Startups - Visit https://www.hubspot.com/startups and join the founders who are turning growth challenges into opportunities. (20:19) Vanta - TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist (30:21) Notion - TWiST listeners can try it for free at https://notion.com/twist * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 14m
  7. 11x in Trouble and China's AI Acceleration | E2103

    MAR 27

    11x in Trouble and China's AI Acceleration | E2103

    OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/twist LinkedIn Ads - To redeem a $100 LinkedIn ad credit and launch your first campaign, go to linkedin.com/thisweekinstartups Brex - the financial stack founders can bank on. Get the business account trusted by 1 in 3 US startups at brex.com/banking-solutions. Today’s show: Jason, Alex, and Lon dig into the controversy around 11x, the Andreessen-backed startup accused of misrepresenting revenue and using fake logos, and what that says about early-stage accountability. Then we break down China’s dual-front blitz in AI and EVs: DeepSeek’s open-source model rivals GPT-4, and Xiaomi’s $30K SU7 is a straight-up Porsche clone shaking the EV market. Finally, we unpack the “4-persona framework” that helped Wiz rocket to $100M+ ARR faster than anyone — a must-know concept for any founder looking to build, sell, and scale like a beast. Timestamps: (0:00) Episode Teaser (1:27) Introduction of co-hosts Lon Harris and Alex Wilhelm (3:23) New set design and color analysis(5:43) Announcement of "Twist OT" and potential Patreon model( 8:09) Gamestop's Bitcoin strategy and Michael Saylor's influence (10:15) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/twist (14:26) MSTR and their shift to Bitcoin (17:01) Michael Saylor’s conflict of interest (20:40) LinkedIn Ads - Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups (23:09) Investment strategies for company treasuries(25:10) Allegations against Eleven x startup (30:35) Brex - the financial stack founders can bank on. Get the business account trusted by 1 in 3 US startups at brex.com/banking-solutions. (32:56) The importance of transparency and accountability in startups (42:31) Chinese advancements in AI technology and ChatGPT features (55:09) Insight from Israeli VC Gili Raanan on successful startups (1:04:26) Founder Friday March Pitch Madness bracket competition (1:10:26) How to start a Founder Friday chapter and community (1:11:21) Bracket competition and Launch Accelerator's 34th cohort * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Lon: X: https://x.com/Lons LinkedIn: https://www.linkedin.com/in/lonharris Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (10:15) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/twist (20:40) LinkedIn Ads - Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups (30:35) Brex - Get the business account trusted by 1 in 3 US startups at https://www.brex.com/banking-solutions Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 14m
  8. 23andMe BANKRUPT, Saylor Still Buying Bitcoin, + Founder Interviews | E2102

    MAR 25

    23andMe BANKRUPT, Saylor Still Buying Bitcoin, + Founder Interviews | E2102

    Today’s show: In this episode, Alex and Lon kick things off with the latest tech news — including 23andMe’s dramatic collapse, MicroStrategy’s half-million Bitcoin haul, and whether we’re finally seeing a rebound in startup M&A. Then they sit down with three standout founders building the future across AI chips, data privacy, and healthcare. First up, Etched CEO Gavin Uberti explains why they’re betting big on transformer-specific ASICs. Then, Skyflow co-founder Anshu Sharma breaks down how they’re helping enterprises use LLMs without leaking private data. Finally, MedServe’s team walks us through how they’re securing medications in outpatient clinics and staying on the right side of the DEA. * Timestamps: (0:00) Alex kicks off the show (1:15) 23andMe bankruptcy and SPACs impact (5:23) MicroStrategy's Bitcoin strategy (8:58) Increase in M&A activity and market trends (10:06) Northwest Registered Agent - Get a 60% discount on your next LLC at https://www.northwestregisteredagent.com/twist (13:37) Browser use, agentic AI, and VC market insights (19:28) Financial responsibility in startups (20:28) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (21:56) Interview with Gavin Uberti of Etched (30:32) Fidelity Private Shares℠ - Visit ⁠https://www.fidelityprivateshares.com ! Mention our podcast and receive 20% off your first-year paid subscription. (32:12) Economic and technical aspects of chip efficiency (39:53) Etched's market demand, manufacturing, and AI scaling (43:05) Founder insights and hardware startup potential (45:43) Introduction to Skyflow and Anshu Sharma (50:19) Skyflow's growth and customer acquisition strategies (1:03:09) ServiceNow's new product and Skyflow's bullish outlook (1:06:33) M&A interest and AI stack value creation (1:12:06) Skyflow's funding and cybersecurity customer trust (1:13:12) Introduction to MedServe and Milwaukee's startup ecosystem (1:16:30) MedServ's solution to drug dispensing and diversion (1:23:05) Economic challenges and solutions for smaller facilities (1:26:50) MedServe cabinet features and use case demonstration (1:29:51) Cybersecurity and physical security of MedServe systems * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Follow Etched: Website: https://www.etched.com/ X: https://x.com/Etched LinkedIn: https://www.linkedin.com/company/etched-ai/ * Follow MedServe: Website: https://medserverx.com/ X: https://x.com/MedServeRX LinkedIn: https://www.linkedin.com/company/medserverx/ * Follow Skyflow: Website: https://www.skyflow.com/ X: https://x.com/SkyflowAPI LinkedIn: https://www.linkedin.com/company/skyflow/ * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Lon: X: https://x.com/Lons * Thank you to our partners: (10:06) Northwest Registered Agent - Get a 60% discount on your next LLC at https://www.northwestregisteredagent.com/twist (20:28) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (30:32) Fidelity Private Shares℠ - Visit https://www.fidelityprivateshares.com ⁠ Mention our podcast and receive 20% off your first-year paid subscription. Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 36m
    4.2
    out of 5
    1,239 Ratings

    About

    Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

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